原创力文档coexistence of the hypersecretion of catecholamine, adrenal cortical nodular hyperplasia, and nephrotic-range proteinuria of focal segmental scleronephrosis is it fat-induced hypertension英文论文.pdfVIP
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coexistence of the hypersecretion of catecholamine, adrenal cortical nodular hyperplasia, and nephrotic-range proteinuria of focal segmental scleronephrosis is it fat-induced hypertension英文论文
International Journal of Clinical Medicine, 2011, 2, 206-211
doi:10.4236/ijcm.2011.23034 Published Online July 2011 (http://www.SciRP.org/journal/ijcm)
Coexistence of the Hypersecretion of
Catecholamine, Adrenal Cortical Nodular
Hyperplasia, and Nephrotic-Range Proteinuria of
Focal Segmental Scleronephrosis: Is It
Fat-Induced Hypertension?
1 1 2 3
Khanh vinh quốc Lương , Lan Thị Hòang Nguyễn , Sĩ văn Nguyễn , Ninh T. Nguyễn
1Vietnamese American Research Foundation, Westminster, USA; 2Department of Pathology/Garden Grove Medical Center, Garden
Grove, USA; 3Department of Surgery/UCI Medical Center, Orange, USA.
Email: Lng2687765@
Received January 1st, 2011; revised March 15th, 2011; accepted April 6th, 2011.
ABSTRACT
Two patients had a long history of hypertension and one of them also had a nephrotic-range proteinuria secondary to
focal segmental scleronephrosis which had been diagnosed by kidney biopsy. They presented with uncontrolled hyper-
tension. Laboratory examination suggested hypersecretion of catecholamines by the left adrenal glands in both patients
and primary aldosteronism in one of them. A computed tomography scan revealed small nodules on left adrenal gland
in both patients. Patients underwent laparoscopic left adrenalectomy. After surgery, blood pressure was normalized
and proteinuria was resolved. Most interestingly, prominent adipocytes infiltrated were detected in the adrenal cortex
and were associated with the presence of lymphocytes, which suggested that adipocytes might have a role in the patho-
genesis of these diseases in our patients.
Keywords : Pheochromocytoma, Aldosteronism, Adipocyte, Nephrotic Syndrome, Focal Segmental Scleronephrosis,
Adrenal Cortical Hyperplasia
1. Introduction pressed adrenal tissue.
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