coffee consumption and cystatin-c-based estimated glomerular filtration rates in healthy young adults results of a clinical trial咖啡消费和健康的年轻成年人cystatin-c-based估计肾小球滤过率临床试验的结果.pdfVIP

Hindawi Publishing Corporation Journal of Nutrition and Metabolism Volume 2011, Article ID 146865, 7 pages doi:10.1155/2011/146865 Clinical Study Coffee Consumption and Cystatin-C-Based Estimated Glomerular Filtration Rates in Healthy Young Adults: Results of a Clinical Trial Masafumi Saito, Tohru Nemoto, Satoshi Tobimatsu, Midori Ebata, Yulan Le, and Kei Nakajima Division of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan Correspondence should be addressed to Kei Nakajima, keinaka@josai.ac.jp Received 18 January 2011; Revised 20 March 2011; Accepted 17 April 2011 Academic Editor: Christel Lamberg-Allardt Copyright © 2011 Masafumi Saito et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Recently it has been reported that the estimated glomerular filtration rate (eGFR) is higher in habitual coffee consumers than in noncoffee consumers. However, the causality remains unclear. Therefore, we conducted a clinical trial to investigate the effects of coffee consumption on kidney function. Nineteen asymptomatic nonsmokers aged 21–27 years old participated in this study. They consumed coffee (18 g coffee beans/450 mL per day) or green tea as a comparator for 2 weeks in a crossover design. Although creatinine-based eGFR was not affected after consuming either beverage, all cystatin-C-based eGFRs determined using five different equations were significantly increased after coffee consumption (means: 5.0–7.7%), but not after green tea consumption (means: 0.1–1.6%). Serum adiponectin an