原创力文档comparison of protein profiles in sputum between copd and acute exacerbation of copd比较蛋白质的概要文件在痰慢性阻塞性肺病和慢性阻塞性肺病急性加重.pdfVIP
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comparison of protein profiles in sputum between copd and acute exacerbation of copd比较蛋白质的概要文件在痰慢性阻塞性肺病和慢性阻塞性肺病急性加重
Open Journal of Respiratory Diseases, 2012, 2, 25-30
/10.4236/ojrd.2012.22004 Published Online May 2012 (http://www.SciRP.org/journal/ojrd)
Comparison of Protein Profiles in Sputum between COPD
and Acute Exacerbation of COPD
1 1 2 2 3
Soo-Taek Uh , Seung Ah Ko , An Soo Jang , Sung Woo Park , Yong-Hoon Kim ,
Young-Ki Paik4, Choon Sik Park2*
1Division of Respiratory and Allergy Medicine, Soonchunhyang University Hospital,
Seoul, South Korea
2Genome Research Center for Allergy and Respiratory Disease, Soonchunhyang University Bucheon Hospital,
Bucheon, South Korea
3Division of Respiratory Medicine, Soonchunhyang University, Chunan Hospital, Asan, South Korea
4Yonsei Proteome Research Center, Department of Biochemistry and Biomedical Science, College of Life Science and
Biotechnology, Yonsei University, Seoul, South Korea
*
Email: uhs@schmc.ac.kr, mdcspark@unitel.co.kr
Received January 25, 2012; revised March 7, 2012; accepted March 15, 2012
ABSTRACT
Background and Objective: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation that is associated with an abnormal inflammatory response of the lung to noxious particles or gases. Cigarette
smoking is the major risk factor for the development of COPD. This study evaluated the levels of cyclophilin B in sputa
from patients with COPD and COPD with acute exacerbation (AECOPD). Materials an
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