comparison of serum apolipoprotein levels of diabetic children and healthy children with or without diabetic parents比较糖尿病儿童和健康儿童血清载脂蛋白水平的有或没有糖尿病的父母.pdfVIP

Hindawi Publishing Corporation Cholesterol Volume 2012, Article ID 490381, 4 pages doi:10.1155/2012/490381 Research Article Comparison of Serum Apolipoprotein Levels of Diabetic Children and Healthy Children with or without Diabetic Parents Mohammad Hashemi,1 Mohammad Saadat,1 Mohaddeseh Behjati,1 and Roya Kelishadi2 1 Cardiology Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 2 Pediatrics Department, Faculty of Medicine and Child Growth Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Correspondence should be addressed to Mohaddeseh Behjati, behjati@med.mui.ac.ir Received 4 April 2012; Accepted 10 May 2012 Academic Editor: Khosrow Adeli Copyright © 2012 Mohammad Hashemi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. The association of diabetes and atherosclerosis with disorders of lipids and lipoproteins, notably high apolipoprotein B (apoB) and low apolipoprotein A1(apoA1) is well established. Because of the beginning of the atherosclerosis’ process from early life, in this study, the plasma levels of apoA1 and apoB were compared in diabetic children with type I diabetes mellitus(DM), healthy children with diabetic parents (HDPs),and healthy children with nondiabetic parents (HNDPs). Methods. This case-control study was conducted among 90 children aged 9–18 years. Serum levels of apoA and apoB were compared among 30 diabetic children (DM), 30 healthy children with diabetic parents (HDPs), and 30 healthy children with nondiabetic parents (HNDP). Results. The mean serum apoA1 was higher in DM (153 ±