computerized segmentation and characterization of breast lesions in dynamic contrast-enhanced mr images using fuzzy c-means clustering and snake algorithm电脑化的分割和描述乳腺病变的动态对比度增强,图像使用模糊c均值聚类算法和蛇.pdfVIP

Hindawi Publishing Corporation Computational and Mathematical Methods in Medicine Volume 2012, Article ID 634907, 10 pages doi:10.1155/2012/634907 Research Article Computerized Segmentation and Characterization of Breast Lesions in Dynamic Contrast-Enhanced MR Images Using Fuzzy c-Means Clustering and Snake Algorithm Yachun Pang,1 Li Li,2 Wenyong Hu,1 Yanxia Peng,2 Lizhi Liu,2 and Yuanzhi Shao1 1 School of Physics and Engineering, Sun Yat-sen University, Guangzhou 510275, China 2 Imaging Diagnosis and Interventional Center, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China Correspondence should be addressed to Yuanzhi Shao, stssyz@ Received 27 February 2012; Revised 18 June 2012; Accepted 18 June 2012 Academic Editor: Huafeng Liu Copyright © 2012 Yachun Pang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This paper presents a novel two-step approach that incorporates fuzzy c-means (FCMs) clustering and gradient vector flow (GVF) snake algorithm for lesions contour segmentation on breast magnetic resonance imaging (BMRI). Manual delineation of the lesions by expert MR radiologists was taken as a reference standard in evaluating the computerized segmentation approach. The proposed algorithm was also compared with the FCMs clustering based method. With a database of 60 mass-like lesions (22 benign and 38 malignant cases), the proposed method demonstrated sufficiently good segmentation performance. The morphological and texture features were extracted and used to classify the benign and malignant lesions based on the proposed computerized segmentation contour and radiologists’ delineation, respectively