consecutive daily measurements of luminal concentrations of lactate in the rectum in septic shock patients每天连续测量腔的乳酸的浓度在脓毒性休克患者的直肠.pdfVIP

Hindawi Publishing Corporation Critical Care Research and Practice Volume 2012, Article ID 504096, 8 pages doi:10.1155/2012/504096 Clinical Study Consecutive Daily Measurements of Luminal Concentrations of Lactate in the Rectum in Septic Shock Patients Michael Ibsen,1 Jørgen Wiis,1 Tina Waldau,2 and Anders Perner1 1 Intensive CareUnit 4131, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark 2 Department of Anaesthesia and Intensive Care, Herlev Hospital, University of Copenhagen, 2730 Herlev, Denmark Correspondence should be addressed to Anders Perner, ap@dadlnet.dk Received 23 August 2011; Revised 31 October 2011; Accepted 29 November 2011 Academic Editor: Maxime Cannesson Copyright © 2012 Michael Ibsen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In a recent study we found no difference in the concentrations of luminal lactate in the rectum between nonsurvivors and survivors in early septic shock (24 h). This study was initiated to investigate if there are any changes in the concentrations of luminal lactate in the rectum during the first 3 days of septic shock and possible differences between nonsurvivors and survivors. Methods. We studied 22 patients with septic shock in this observational study. Six to 24 h after the onset of septic shock the concentration of lactate in the rectal lumen was estimated by 4 h equilibrium dialysis (day 1). The rectal dialysis was repeated on day 2 and day 3. Results. The concentration of lactate in the rectal lumen did not change over the 3 days in neither nonsurvivors nor survivors. Rectal luminal and arterial lactate concentrations were not di