copper nanoparticles as modulators of apoptosis and structural changes in tissues铜纳米粒子作为细胞凋亡的调节器和结构组织的变化.pdfVIP

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copper nanoparticles as modulators of apoptosis and structural changes in tissues铜纳米粒子作为细胞凋亡的调节器和结构组织的变化.pdf

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copper nanoparticles as modulators of apoptosis and structural changes in tissues铜纳米粒子作为细胞凋亡的调节器和结构组织的变化

Journal of Biomaterials and Nanobiotechnology, 2012, 3, 97-104 97 /10.4236/jbnb.2012.31013 Published Online January 2012 (http://www.SciRP.org/journal/jbnb) Copper Nanoparticles as Modulators of Apoptosis and Structural Changes in Tissues 1 1 2 3 1 Elena Sizova , Sergey Miroshnikov , Valentina Polyakova , Natalia Gluschenko , Anatoly Skalny 1Orenburg State University, Orenburg, Russia; 2Orenburg State Medical Academy of Federal Agency in Public Health and Social Development, Orenburg, Russia; 3Institute of Energy Problems in Chemical Physics RAS, Moscow, Russia. Email: Sizova.L78@yandex.ru Received October 16th, 2011; revised November 29th, 2011; accepted December 20th, 2011 ABSTRACT Results of research on copper nanoparticles influence on index of readiness to apoptosis and structural changes of liver, spleen, kidney tissues as well as sensomotor cerebral cortex under copper multiple introductions into organism of ani- mals are presented in the article. It is established that copper nanoparticles distribute in organs and tissues of animals and cause specific structural changes. The increase of copper nanoparticles in organism up to toxical threshold (maxi- mum tolerated dose) results in dystrophy and tissue necrosis. Accurate expression enhancement of Caspase 3 in micro- gliocytes (brain macrophages) has been registered seven days after one-fold intramuscular introduction of copper nanoparticles (dose 2 mg/kg of animal body weight), in liver cells—three and seven days after three-fold intramuscular introduction of copper nanoparticles (total dose was 6 mg/kg of animal body weight), in proximal kidney tubules-three hours, one, three and seven days after three-fold intramuscular introduction of copper nanoparticles (with tot