原创力文档cytomegalovirus infection modulates cellular immunity in an experimental model for autoimmune diabetes巨细胞病毒感染调节细胞免疫在自身免疫性糖尿病的实验模型.pdfVIP
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cytomegalovirus infection modulates cellular immunity in an experimental model for autoimmune diabetes巨细胞病毒感染调节细胞免疫在自身免疫性糖尿病的实验模型
Clinical Developmental Immunology, June–December 2003 Vol. 10 (2–4), pp. 153–160
Cytomegalovirus Infection Modulates Cellular Immunity in an
Experimental Model for Autoimmune Diabetes
a a a a b
NIENKE VAN DER WERF , JAN-LUUK HILLEBRANDS , FLIP A. KLATTER , INEKE BOS , CATHRIEN A. BRUGGEMAN and
JAN ROZINGa,*
aFaculty of Medical Sciences, Department of Cell Biology, Immunology Section, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen,
The Netherlands; bDepartment of Medical Microbiology, University Hospital Maastricht, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands
Background : Viral infections are thought to play a role in the development of autoimmune diseases
like type 1 diabetes. In this study we investigated the effect of Rat Cytomegalovirus (RCMV) infection
on cellular immunity in a well-defined animal model for diabetes, the Biobreeding (BB) rat.
Methods : Diabetes prone (DP)- and Diabetes resistant (DR)-BB rats were infected with 2 £ 106
plaque forming units (pfu) RCMV. Diabetes development was monitored by frequent blood-glucose
analysis. Effects of RCMV on CD4þ, CD8þ and Vb-TCRþ T-cell subsets were measured in vivo, and
in vitro after restimulation with RCMV-infected fibroblasts. Proliferative capacity was determined by
3H-Thymidine incorporation.
Results : RCMV-infection resulted in a significant acceleration of diabetes onset in DP-BB rats
ðp ¼ 0:003Þ. Percentages CD4þ and CD8þ T-cells were not affected in vivo. In vitro, RCMV-
r
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