cytotoxic t lymphocyte-associated antigen +49g variant confers risk for anti-ccp- and rheumatoid factor-positive type of rheumatoid arthritis only in combination with ct60？g allele英文论文.pdfVIP

SAGE-Hindawi Access to Research Autoimmune Diseases Volume 2010, Article ID 285974, 5 pages doi:10.4061/2010/285974 Research Article Cytotoxic T lymphocyte-Associated Antigen +49G Variant Confers Risk for Anti-CCP- and Rheumatoid Factor-Positive Type of Rheumatoid Arthritis Only in Combination with CT60∗G Allele Bernadett Farago, Peter Kisfali, Lili Magyari, Noemi Polgar, and Bela Melegh Department of Medical Genetics and Child Development, University of Pecs, Pecs 7624, Hungary Correspondence should be addressed to Bela Melegh, bela.melegh@aok.pte.hu Received 4 June 2009; Accepted 2 August 2009 Academic Editor: Rizgar Mageed Copyright © 2010 Bernadett Farago et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Controversial observations have been published on the association of the cytotoxic T lymphocyte associated antigen gene’s variants with rheumatoid arthritis (RA). After genotyping 428 patients and 230 matched controls, the prevalence of the CT60∗G allele was more frequent in RF- and/or anti-CCP-seropositive RApatients, compared to the healthy controls (P .001). Regression analysis revealed that the CT60∗G allele is a possible predisposing factor for RA in these subgroups. No accumulation of the +49∗G allele was found among patients, and this variant was not found to correlate with RA. Assaying the possible genotype variations, the +49∗G-CT60∗G allelic combination was accumulated in seropositive RA-subtypes, and was associated with the risk of RA (OR = 1.73, P = .001 for the whole RA-population). Although the +49∗G allele did not mean a predisposition to RA alone, in combination with