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cytosolic phospholipase a2 s-nitrosylation in ghrelin protection against detrimental effect of ethanol cytotoxicity on gastric mucin synthesis ——ghrelin in gastric mucosal protection英文论文.pdf

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cytosolic phospholipase a2 s-nitrosylation in ghrelin protection against detrimental effect of ethanol cytotoxicity on gastric mucin synthesis ——ghrelin in gastric mucosal protection英文论文

Vol.2, No.9, 1033-1039 (2010) Health doi:10.4236/health.2010.29152 Cytosolic phospholipase A S-nitrosylation in ghrelin 2 protection against detrimental effect of ethanol cytotoxicity on gastric mucin synthesis ——Ghrelin in gastric mucosal protection Bronislaw L. Slomiany, Amalia Slomiany Research Center University of Medicine and Dentistry of New Jersey Newark, Newark, USA; Corresponding Author: slomiabr@ Received 12 March 2010; revised 8 April 2010; accepted 11 April 2010. ABSTRACT 1. INTRODUCTION Ghrelin, a peptide hormone produced mainly in Acute gastric mucosal lesions, mucosal inflammatory the stomach, has emerged recently as an im- changes, and gastro-duodenal ulceration are well-recogni- portant regulator of nitric oxide synthase (NOS) zed consequences of alcohol abuse on the health of gas- and cyclooxygenase (COX) enzyme systems, trointestinal tract [1-3]. The gastric mucosal responses to the products of which play direct cytoprotective ethanol cytotoxicity are manifested by microcirculatory function in the maintenance of gastric mucosal changes, elevation in proinflammatory cytokine produc- integrity. In this study, using gastric mucosal tion, enhancement in epithelial cell apoptosis, and the cells, we report on the role of g