dabco promoted an efficient and convenient synthesis of pyrrole in aqueous mediumdabco提拔一个高效、方便的合成吡咯在水介质.pdfVIP

International Journal of Organic Chemistry, 2012, 2, 159-165 / 10.4236/ijoc.2012.22024 Published Online June 2012 (http://www.SciRP.org/journal/ijoc) DABCO Promoted an Efficient and Convenient Synthesis of Pyrrole in Aqueous Medium * Harshadas Mitaram Meshram , Vikas Madhukar Bangade, Bandi Chennakesava Reddy, Gudimella Santosh Kumar, Pramod Bhagwan Thakur Discovery Laboratory, Organic Chemistry Division—I, Indian Institute of Chemical Technology, Hyderabad, India * Email: hmmeshram@ Received February 11, 2012; revised March 23, 2012; accepted April 1, 2012 ABSTRACT The synthesis of C-substituted and N-substituted pyrrole is described by the reaction of phenacyl bromides, pentane-2, 4-dione and amine in aqueous medium using DABCO as a catalyst. The method is very convenient and applicable for alkyl as well as aryl amines and phenacyl bromides. The procedure is amenable for the synthesis of new substituted pyrroles. Moreover, aqueous medium makes the method more eco-friendly. Keywords: Phenacyl Bromide; Pentane-2,4-Dione; Amines; DABCO; Water; Pyrroles 1. Introduction dium because it is safest and abundantly available solvent. Very recently, 1,4-diaza-bicyclo[2.2.2]octane (DABCO) The pyrrole ring is found in porphyrin, bile pigment and has emerged as a promoter for various organic reactions in bioactive natural products [1-3]. Pyrrole oligomers [16-21]. It is