原创力文档cytotoxicity and selectivity in skin cancer by sapc-dops nanovesicles细胞毒性和选择性的皮肤癌sapc-dops nanovesicles.pdfVIP
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cytotoxicity and selectivity in skin cancer by sapc-dops nanovesicles细胞毒性和选择性的皮肤癌sapc-dops nanovesicles
Journal of Cancer Therapy, 2012, 3, 321-326 321
/10.4236/jct.2012.34041 Published Online August 2012 (http://www.SciRP.org/journal/jct)
Cytotoxicity and Selectivity in Skin Cancer by SapC-DOPS
Nanovesicles
1 1,2 1,2 3 1,2*
Shadi Abu-Baker , Zhengtao Chu , Ashley M. Stevens , Jie Li , Xiaoyang Qi
1Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati,
USA; 2Division of Human Genetics, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA;
3Department of Dermatology, University of Miami, Miami, USA.
*
Email: xiaoyang.qi@
Received June 20th, 2012; revised July 25th, 2012; accepted August 9th, 2012
ABSTRACT
Squamous cell carcinoma (SCC) and melanoma are malignant human cancers of the skin with an annual mortality that
exceeds 10,000 cases every year in the USA alone. In this study, the lysosomal protein saposin C (SapC) and the phos-
pholipid dioloylphosphatidylserine (DOPS) were assembled into cancer-selective nanovesicles (SapC-DOPS) and suc-
cessfully tested using several in vitro and in vivo skin cancer models. Using MTT assay that measures the percentage of
cell death, SapC-DOPS cytotoxic effect on three skin tumor cell lines (squamous cell carcinoma, SK-MEL-28, and
MeWo) was compared to two normal nontumorigenic skin cells lines, normal immortalized keratinocyte (NIK) and
human fibroblast cell (HFC). We observed that the nanovesicles selectively killed the skin cancer cells by inducing
apoptotic cell death whereas untransformed skin cancer cells remaine
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