原创力文档cytotoxic effect of dexamethasone restricted to noncycling, early g1 phase of melanoma cells地塞米松限于noncycling细胞毒性效应,早期黑色素瘤细胞g1期.pdfVIP
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cytotoxic effect of dexamethasone restricted to noncycling, early g1 phase of melanoma cells地塞米松限于noncycling细胞毒性效应,早期黑色素瘤细胞g1期
Journal of Cancer Therapy, 2011, 2, 253-257 253
doi:10.4236/jct.2011.22032 Published Online June 2011 (http://www.SciRP.org/journal/jct)
Cytotoxic Effect of Dexamethasone Restricted to
Noncycling, Early G1 Phase of Melanoma Cells
*
Abdel-Moneim M. Osman , Mansour I. Sulaiman, Zoheir A. Damanhouri
Pharmacology Department, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Email: moneimosman@
th th st
Received May 18 , 2010; revised May 10 , 2011; accepted May 21 , 2011.
ABSTRACT
This study deals with the inhibitory effects of dexamethsone on the proliferation of a human melanoma cells after sepa-
ration into different fractions according to their position in the cell cycle using a gravity sedimentation chamber. Frac-
tions with high percentage of G1 cells were more susceptible to the action of dexamethsone than those with a lower
percentage of G 1 cells. Dexamethsone stimulated the rate of incorporation of radioactive precursors into acid-pre-
cipitable materials of melanoma M-5A cells starting 24 hours after treatment for one hour. Moreover, dexamethsone
treatment markedly increased the volume of the M-5A cells with increasing the possibility of stimulating the transcrip-
tional/translational activity in the cells. This study may hopefully stimulate the development of new approaches in sys-
temic and/or regional chemotherapy with malignant melanoma using dexamethsone with other alkylating agents to get
synergestic interaction.
Keywords : Melanoma Cells , Cell Fractionation, Dexamethasone
1. Introduction bition of cell proliferation by glucocorticoid [6] raised
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