原创力文档cytoplasmic ribonucleoprotein foci in eukaryotes hotspots of bio(chemical)diversity细胞质核糖核蛋白焦点在真核生物生物(化学)多样性的热点.pdfVIP
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cytoplasmic ribonucleoprotein foci in eukaryotes hotspots of bio(chemical)diversity细胞质核糖核蛋白焦点在真核生物生物(化学)多样性的热点
Hindawi Publishing Corporation
Comparative and Functional Genomics
Volume 2012, Article ID 504292, 7 pages
doi:10.1155/2012/504292
Review Article
Cytoplasmic Ribonucleoprotein Foci in Eukaryotes: Hotspots of
Bio(chemical)Diversity
Carla Layana,1, 2 Paola Ferrero,1, 2 and Rolando Rivera-Pomar1, 2
1 Centro Regional de Estudios Genomicos, Universidad Nacional de La Plata, CP 1888 Florencio Varela, Argentina
´
2 Departamento de Ciencias Basicas y Experimentales, Universidad Nacional del Noroeste de Buenos Aires,
´
Avenida Calchaquı 5900, CP 1888 Buenos Aires, Pergamino, Argentina
´
Correspondence should be addressed to Rolando Rivera-Pomar, rrivera@unnoba.edu.ar
Received 1 February 2012; Accepted 22 March 2012
´
Academic Editor: Greco Hernandez
Copyright © 2012 Carla Layana et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The life of an mRNA from transcription to degradation offers multiple control check points that regulate gene expression.
Transcription, splicing, and translation have been widely studied for many years; however, in recent years, new layers of
posttranscriptional and posttranslational control have been uncovered. They involve the regulation of the metabolism of mRNA
in cytoplasmic foci. They are collections of ribonucleoprotein complexes that, in most cases, remain still uncharacterized, except
the processing bodies (PBs) and stress granules (SGs), which have been studied (and reviewed) in detail. A challengin
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