descriptively probabilistic relationship between mutated primary structure of von hippel-lindau protein and its clinical outcome叙述地变异概率关系的主要结构冯hippel-lindau蛋白质和其临床结果.pdfVIP

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descriptively probabilistic relationship between mutated primary structure of von hippel-lindau protein and its clinical outcome叙述地变异概率关系的主要结构冯hippel-lindau蛋白质和其临床结果.pdf

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descriptively probabilistic relationship between mutated primary structure of von hippel-lindau protein and its clinical outcome叙述地变异概率关系的主要结构冯hippel-lindau蛋白质和其临床结果

J. Biomedical Science and Engineering, 2009, 2, 190-199 JBiSE Descriptively probabilistic relationship between mutated primary structure of von Hippel-Lindau protein and its clinical outcome Shao-Min Yan1, Guang Wu2* 1 National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, 98 Daling Road, Nanning, Guangxi Province, CN-530007, China; 2Computational Mutation Project, DreamSciTech Consulting, 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong Province CN-518054, China; *Corresponding author (hongguanglishibahao@), Tel: +86 771 2503 930, Fax: +86 755 2664 8177. Received 5 August 2008; revised 4 January 2009; accepted 7 January 2009. ABSTRACT to quantify a protein sequence, for example, to use the physicochemical property of amino acid to quantify a In this study, we use the cross-impact analysis protein sequence [1]. to build a descriptively probabilistic relationship Since 1999, we have developed three approaches to between mutant von Hippel-Lindau protein and quantify each amino acid in a protein as well as a whole its clinical outcome after quantifying mutant protein (for reviews, see [2,3,4]), and our quantifications von Hippel-Lindau proteins with the amino-acid indeed differ before and after mutation, thus it is possi- distribution probability, then we use the Bayes- ble to use our approaches to build a quantitative rela- ian equation to determine the probability that tionship between changed primary structure and changed the von Hippel-Li