development of protective antibodies to streptococcus pneumoniae in healthy children发展的保护性抗体在健康儿童肺炎链球菌.pdfVIP

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development of protective antibodies to streptococcus pneumoniae in healthy children发展的保护性抗体在健康儿童肺炎链球菌.pdf

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development of protective antibodies to streptococcus pneumoniae in healthy children发展的保护性抗体在健康儿童肺炎链球菌

Open Journal of Pediatrics, 2012, 2, 42-46 OJPed /10.4236/ojped.2012.21006 Published Online March 2012 (http://www.SciRP.org/journal/ojped/) Development of protective antibodies to Streptococcus pneumoniae in healthy children 1 2 1* David Björnheden , Bertil Kaijser , Bill Hesselmar 1Institute for Clinical Science, Department of Paediatrics, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden 2Department of Clinical Bacteriology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden * Email: bill.hesselmar@vgregion.se Received 10 June 2011; revised 22 September 2011; accepted 20 October 2011 ABSTRACT as often in 3 - 5 year olds as compared to teenagers, and amoxicillin eight times as often. Infections due to Strep- Aim: To study how immunity to Streptococcus pneu- tococcus pneumoniae are common in both children and moniae normally develops in healthy children. Meth- adults, and pneumococci are the cause in about one third ods: Ninety two healthy children at 3 - 5, 7 - 9 and 13 - of all community acquired pneumonias in children [1]. 15 years of age were recruited. No one of the children Pneumococci is also commonly found in otitis media in had previously been given pneumococcal vaccine.