原创力文档differences of heart rate variability during sevoflurane anesthesia in children by age七氟醚麻醉时不同的心率变异性在儿童时代.pdfVIP
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differences of heart rate variability during sevoflurane anesthesia in children by age七氟醚麻醉时不同的心率变异性在儿童时代
Open Journal of Anesthesiology, 2012, 2, 74-78 1
/ 10.4236/ojanes.2012.23018 Published Online July 2012 (http://www.SciRP.org/journal/ojanes)
Differences of Heart Rate Variability during Sevoflurane
Anesthesia in Children by Age
1 1 1 1 2
Yong-Hee Park , Chang-Hoon Koo , Jin-Tae Kim , Hee-Soo Kim , Hyo-Jin Byon
1Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, Korea; 2Department of
Anesthesiology and Pain Medicine, College of Medicine, Inha University, Incheon, Korea.
Email: dami0605@snu.ac.kr
Received April 3rd, 2012; revised May 6th, 2012; accepted May 30th, 2012
ABSTRACT
Background: The child’s central nervous system develops with aging, and heart rate variability (HRV), which is con-
trolled by the brain, differs from that of adults. We investigated changes in HRV during sevoflurane anesthesia in chil-
dren. Methods: One 138 children aged from 2 - 12 years without major underlying problems were enrolled. During
maintenance with 2 - 2.5 vol% sevoflurane anesthesia, electrocardiographic data were obtained and power spectral
analysis, approximate entropy (ApEn) or Hurst exponent were analyzed and compared in three groups (age 2 - 5 years,
6 - 9 and 10 - 12 years of age). Results: The RR interval increased with aging, but low-frequency powers did not. High-
frequency power was greater in the oldest children (P 0.05), while ApEn and Hurst exponents were lower (P 0.05).
Conclusion: Change in HRV is one of the characteristics of development in children.
Keywords: Children; Heart Rate Variability; Sevoflurane
1. Introduction induction of anesthesia may depress parasympathetic ac-
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