different activity of the biological axis vegf-flt-1 (fms-like tyrosine kinase 1) and cxc chemokines between pulmonary sarcoidosis and idiopathic pulmonary fibrosis a bronchoalveolar lavage study英文论文.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2009, Article ID 537929, 8 pages doi:10.1155/2009/537929 Research Article Different Activity of the Biological Axis VEGF-Flt-1 (fms -Like Tyrosine Kinase 1) and CXC Chemokines between Pulmonary Sarcoidosis and Idiopathic Pulmonary Fibrosis: A Bronchoalveolar Lavage Study Katerina M. Antoniou,1 Giannoula Soufla,2 Athanasia Proklou,1 George Margaritopoulos,1 Christiana Choulaki,3 Rena Lymbouridou,2 Katerina D. Samara,1 Demetrios A. Spandidos,2 and Nikolaos M. Siafakas1 1 Department of Thoracic Medicine, University Hospital, Medical School, University of Crete, Heraklion, 71110 Crete, Greece 2 Laboratory of Virology, Medical School, University of Crete, Heraklion, Greece 3 Department of Rheumatology, Clinical Immunology and Allergy, University Hospital, University of Crete, Heraklion, Greece Correspondence should be addressed to Katerina M. Antoniou, katerinaantoniou@yahoo.gr Received 15 July 2009; Revised 27 September 2009; Accepted 7 December 2009 Recommended by C. Pauza Background. We have previously shown a different local and systemic angiogenic profile of CXC chemokines in Idiopathic Pulmonary Fibrosis (IPF) patients compared to sarcoidosis. In particular, sarcoidosis showed an angiostatic microenvironment, as compared with the angiogenic cytokine milieu seen in IPF. Purpose of the Study. Our aim was to further investigate the aforementioned finding by measuring the expression of different chemokines in granulomatous and fibrotic diseases. We estimated the levels of vascular endothelial growth factor (VEGF) and its high-affinity receptor, Flt-1 (fms -like tyrosine kinase 1), in bronchoalveolar lavage fluid (BALF) of patients with IPF and pulmonary