dietary sugars inhibit biologic functions of the pattern recognition molecule, mannose-binding lectin饮食糖抑制模式识别的生物功能分子,mannose-binding凝集素.pdfVIP

Vol.1, No.2, 41-49 (2011) Open Journal of Immunology doi:10.4236/oji.2011.12005 Dietary sugars inhibit biologic functions of the pattern recognition molecule, mannose-binding lectin 1 1 1 2 3 Kazue Takahashi , Wei-Chuan Chang , Patience Moyo , Mitchell R. White , Parool Meelu , Anamika Verma2 4 2 3* , Gregory L. Stahl , Kevan L. Hartshorn , Vijay Yajnik 1Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Bos- ton, USA; 2Department of Medicine, Boston University School of Medicine, Boston, USA; 3Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, USA; * Corresponding Author: ktakahashi1@ 4Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institute of Medicine, Harvard Medical School, Boston, USA. Received 17 August 2011; revised 1 September 2011; accepted 9 September 2011. ABSTRACT observed in patients with diabetes and obesity. These diseases have been linked to excess consumption of Mannose-binding lectin (MBL), a mammalian le- fructose and fatty foods [5,6]. Fructose, in the form of ctin, is a pattern recognition molecule of the in- high fructose corn syrup, along with sucrose i