原创力文档development of oral dissolving gelatin beads containing allopurinol for the prevention and treatment of mucositis发展包含别嘌呤醇口服溶凝胶珠的粘膜炎的预防和治疗.pdfVIP
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development of oral dissolving gelatin beads containing allopurinol for the prevention and treatment of mucositis发展包含别嘌呤醇口服溶凝胶珠的粘膜炎的预防和治疗
Pharmacology Pharmacy, 2012, 3, 295-299 295
/10.4236/pp.2012.33039 Published Online July 2012 (http://www.SciRP.org/journal/pp)
Development of Oral Dissolving Gelatin Beads Containing
Allopurinol for the Prevention and Treatment of Mucositis
1* 1 1 2 2
Yoshifumi Murata , Takashi Isobe , Kyoko Kofuji , Masafumi Mizutani , Ryosei Kamaguchi
1Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa, Japan; 2Morishita Jintan Co. Osaka Technocenter, Hirakata,
Japan.
*
Email: y-murata@hokuriku-u.ac.jp
Received March 14th, 2012; revised April 20th, 2012; accepted May 26th, 2012
ABSTRACT
Oral dissolving gelatin beads (GBs) containing allopurinol (AP) were prepared by the seamless capsule method and
their rheological properties were examined. The release profiles of both gelatin and AP from GBs were also investi-
gated in limited dissolution medium. GBs containing AP provided an easy-to-handle dosage form, but the physical
strength of the beads immediately decreased upon contact with physiological saline at 37˚C. Gelatin was released from
the outer layer of GBs in physiological saline, with almost all the gelatin dissolved after 5 min, together with approxi-
mately 30% of the AP contained in the inner layer of the GB. The oral administration of GBs likely results in immediate
softening of the GB upon contact with saliva. The released AP acts directly at inflammation sites, in a manner similar
following oral rinsing with an AP suspension. Therefore, GBs are a useful dosage form for preventing or treating local-
ized problems in the oral cavity, such as mucositis.
Keywords: Gelatin Bead; Seamless Capsule; Oral Mucositis; Allopurinol
1. Introduction
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