different implications of paternal and maternal atopy for perinatal ige production and asthma development不同含义的父亲和孕产妇围产期ige生产特异反应性和哮喘的发展.pdfVIP

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different implications of paternal and maternal atopy for perinatal ige production and asthma development不同含义的父亲和孕产妇围产期ige生产特异反应性和哮喘的发展.pdf

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different implications of paternal and maternal atopy for perinatal ige production and asthma development不同含义的父亲和孕产妇围产期ige生产特异反应性和哮喘的发展

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 132142, 10 pages doi:10.1155/2012/132142 Review Article Different Implications of Paternal and Maternal Atopy for Perinatal IgE Production and Asthma Development Chih-Chiang Wu,1, 2 Rong-Fu Chen,2 and Ho-Chang Kuo3, 4 1 Department of Pediatrics, Show Chwan Memorial Hospital, 6 Lu-Kung Road, Lu-Kong, Changhua 50544, Taiwan 2 Department of Medical Research, Show Chwan Medical System in Chang Bing, Changhua 50544, Taiwan 3 Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan 4 Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan Correspondence should be addressed to Chih-Chiang Wu, phachang@ Received 29 July 2011; Accepted 3 October 2011 Academic Editor: Shau-Ku Huang Copyright © 2012 Chih-Chiang Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Asthma is a hereditary disease associated with IgE-mediated reaction. Whether maternal atopy and paternal atopy have diﬀerent impacts on perinatal IgE production and asthma development remains unclear. This paper reviews and summarizes the eﬀects of maternal and paternal atopy on the developmental aspects of IgE production and asthma. Maternal atopy aﬀects both pre- and postnatal IgE production, whereas paternal atopy mainly aﬀects the latter. Maternally transmitted genes GSTP1 and FceRI-beta are associated with lung function and allergic sensitization, respectively. In IgE production and asthma development, the maternal inﬂuence on