differential effects of angiotensin ii on intra-renal hemodynamics in rats; contribution of prostanoids, no and k+ channels微分作用的血管紧张素ⅱintra-renal在大鼠血流动力学;.pdfVIP

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differential effects of angiotensin ii on intra-renal hemodynamics in rats; contribution of prostanoids, no and k+ channels微分作用的血管紧张素ⅱintra-renal在大鼠血流动力学;.pdf

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differentialeffectsofangiotensiniionintra-renalhemodynamicsinrats;contributionofprostanoids,noandkchannels微分作用的血管紧张素ⅱintra-renal在大鼠血流动力学;

Pharmacology Pharmacy, 2012, 3, 388-396 1 /10.4236/pp.2012.34052 Published Online October 2012 (http://www.SciRP.org/journal/pp) Differential Effects of Angiotensin II on Intra-Renal Hemodynamics in Rats; Contribution of Prostanoids, NO + and K Channels 1* 1 2 Ighodaro Igbe , Eric K. I. Omogbai , Adebayo O. Oyekan 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria; 2Center for Cardio- vascular Diseases, College of Pharmacy and Health Sciences, Texas Southern University, Houston, USA. * Email: igbe.ighodaro@ Received May 22nd, 2012; revised June 24th, 2012; accepted July 15th, 2012 ABSTRACT Many agents are known to cause qualitative and quantitative differences in intrarenal blood flow. This study tested the hypothesis that angiotensin II (AII) evokes a differential effect on cortical (CBF) and medullary blood flow (MBF) and that AT2 receptor mediates AII-induced increase in renal MBF by mechanisms related to nitric oxide (NO) and prostanoids. AII (100, 300 and 1000 µg/kg/min) increased mean arterial blood pressure (MABP) by 24% ± 7% (p 0.05); decreased CBF by 30% ± 2% (p 0.05); but increased MBF by 21% ± 8% (p 0.05). Indomethacin (5 mg/kg), enhanced AII effects on MABP by 154% ± 26% (p 0.05), MBF by 141% ± 46% but decreased CBF by 74% ± 54% (p 0.05) indicating the involvement of dilator prostanoids in the systemic and medullary circulation but constrictor prostanoids in the cortex. NG nitro-L-arginine (L-NNA), an inhibitor of NO synthase (100 mg/L in drinking water) en- hanced AII effects on MABP (169 ± 75, p 0.05) and decreased CBF (107% ± 50%, p 0.05) but blunted the effects of AII on MBF (150% ± 21%, p 0.05).