differential effects of k+ channel blockers on phasic contractility of transverse and longitudinal rat detrusor strips微分k +通道阻滞剂对相位的横向和纵向老鼠逼尿肌条的收缩性.pdfVIP

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differential effects of k+ channel blockers on phasic contractility of transverse and longitudinal rat detrusor strips微分k +通道阻滞剂对相位的横向和纵向老鼠逼尿肌条的收缩性.pdf

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differentialeffectsofkchannelblockersonphasiccontractilityoftransverseandlongitudinalratdetrusorstrips微分k通道阻滞剂对相位的横向和纵向老鼠逼尿肌条的收缩性

Open Journal of Urology, 2011, 1, 60-65 doi:10.4236/oju.2011.13013 Published Online August 2011 (http://www.SciRP.org/journal/oju) + Differential Effects of K Channel Blockers on Phasic Contractility of Transverse and Longitudinal Rat Detrusor Strips 1 1 1,2 Aneira Gracia Hidayat Santoso , Wan Ning Lo , Willmann Liang 1School of Biological Sciences, College of Science, Nanyang Technological University, Singapore City, Singapore 2Institute of Advanced Studies, Nanyang Technological University, Singapore City, Singapore E-mail : willmannliang@ Received May 30, 2011; revised June 28, 2011; accepted July 5, 2011 Abstract Spontaneous phasic contractions of detrusor smooth muscle are pivotal to the normal bladder filling process. The role of K+ channels in mediating phasic contractions has been investigated on different occasions, but only in detrusor strips isolated longitudinally. In this study, the effects of individual K+ blockers were exam- ined in both transverse and longitudinal detrusor strips. Detrusor strips were isolated transversely and longi- tudinally from young adult rat bladders. Tension before and after the introduction of K+ channel blockers was measured using a myograph. Phasic activity was determined by calculating the integral of tension fluc- tuations. Phasic activity of transverse strips was increased under tetraethylammonium chloride (TEA), 4-aminopyridine (4-AP) and iberiotoxin (IbTx) treatments. Longitudi