原创力文档diphtheria and tetanus antibody persistence in indian pre-school children and response to a booster dose of dt vaccine.印度学龄前儿童白喉和破伤风抗体持久性和响应dt的助推器剂量疫苗。.pdfVIP
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diphtheria and tetanus antibody persistence in indian pre-school children and response to a booster dose of dt vaccine.印度学龄前儿童白喉和破伤风抗体持久性和响应dt的助推器剂量疫苗。
World Journal of Vaccines, 2011, 1, 5-9
doi:10.4236/wjv.2011.11002 Published Online February 2011 (http://www.SciRP.org/journal/wjv)
Diphtheria and Tetanus Antibody Persistence in
Indian Pre-school Children and Response to a
Booster dose of DT Vaccine
1 2 1 3
Ajit M. Satwekar , Shireen S. Telang , Nilesh A. Ghorpade , Prajakt J. Barde ,
3 3*
Moreshwar R. Patwardhan , Prasad S. Kulkarni
1Jalna Mission Hospital, Jalna; 2Sahyadri Hospital, Pune; 3Serum Institute of India Ltd., Pune; *Additional Medical Director, Serum
Institute of India Ltd 212/2, Hadapsar, Pune-411028, India
Email: drpsk@
Received January 7th th st
, 2011; revised February 20 , 2011; accepted February 21 , 2011.
ABSTRACT
Despite effective vaccines, diphtheria (D) resurged recently in the former socialistic block, and tetanus (T) still occurs
in less privileged countries. We studied the antibody persistence for D and T in Indian pre-school children who had
received four doses of DTP vaccine and subsequently, the response to a booster dose. Anti-D and anti-T IgG antibodies
prior to and one month after a DT vaccine were measured by ELISA in 223 healthy children of 4-6 years who had pre-
viously received four doses of the triple vaccine. Adverse reactions were monitored for one month. While 30% and 14%
of subjects were susceptible to D and T, respectively, 98% and 100% of them attained seroprotection post-vaccination.
Both responses were significant. Local, but not systemic reactions except fever were rather common. A high proportion
of the Indian pre-school population is susceptible to D and T, despite of receiving four doses. The current policy of giv-
ing the fifth dose at this age is appropriate.
Keywords : Diphtheria, Tetanus, Anti
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