dialectics and implications of natural neurotropic autoantibodies in neurological disease and rehabilitation辩证法和影响自然亲神经的自身抗体在神经系统疾病和康复.pdfVIP

Clinical Developmental Immunology, June 2004, Vol. 11 (2), pp. 151–156 Dialectics and Implications of Natural Neurotropic Autoantibodies in Neurological Disease and Rehabilitation a, a a b b b A.B. POLETAEV *, A.A. ABROSIMOVA , M.A. SOKOLOV , A.B. GEKHT , V.V. ALFEROVA , E.I. GUSEV , T.YA. NIKOLAEVAc and C. SELMId aMedical Research Center “Immunculus”, 14 Otkrytoje Shosse 107370 Moscow, Russia; bDepartment of Neurology, Russian State Medical University, Moscow, Russia; c Yakutian State Research Center, Yakutsk, Russia; dDivision of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA, USA The role of natural idiotypic (Id-Abs) and anti-idiotypic (AId-Abs) autoantibodies against neuro- antigens observed in different neurological disorders is not fully understood. In particular, limited experimental evidence has been provided concerning the qualitative and quantitative serological response after acute injuries of the central nervous system or during chronic mental diseases. In this study, we analyzed the specific Id-Abs and AId-Abs serological reactivities against 4 neuro-antigens in a large population of patients with ischemic stroke, schizophrenia, as well as healthy individuals. Patients with ischemic stroke were tested at different time points following the acute stroke episode and a correlation was attempted between autoantibodies response and different patterns of functional recovery. Results showed variable and detectabl