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dna-metallodrugs interactions signaled by electrochemical biosensors an overview电化学生物传感器概述dna-metallodrugs交互信号
Hindawi Publishing Corporation
Bioinorganic Chemistry and Applications
Volume 2007, Article ID 91078, 11 pages
doi:10.1155/2007/91078
Review Article
DNA-Metallodrugs Interactions Signaled by
Electrochemical Biosensors: An Overview
Mauro Ravera,1 Graziana Bagni,1, 2 Marco Mascini,2 and Domenico Osella1
1 Dipartimento di Scienze dell’Ambiente e della Vita, Universita del Piemonte Orientale, Via Bellini 25g,
`
15100 Alessandria, Italy
2 Dipartimento di Chimica, Universita di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino Florence, Italy
`
Received 2 April 2007; Accepted 19 June 2007
Recommended by Viktor Brabec
The interaction of drugs with DNA is an important aspect in pharmacology. In recent years, many important technological ad-
vances have been made to develop new techniques to monitor biorecognition and biointeraction on solid devices. The interaction
between DNA and drugs can cause chemical and conformational modifications and, thus, variation of the electrochemical prop-
erties of nucleobases. The propensity of a given compound to interact with DNA is measured as a function of the decrease of
guanine oxidation signal on a DNA electrochemical biosensor. Covalent binding at N7 of guanine, electrostatic interactions, and
intercalation are the events that this kind of biosensor can detect. In this context, the interaction between a panel of antitumoral
Pt-, Ru-, and Ti-based metallodrugs with DNA immobilized on screen-printed electrodes has been studied. The DNA biosensors
are used for semiquantitative evaluation of the analogous interaction occurring in the biological environment.
Copyright © 2007 Mauro Ravera et al. This is an open access articl
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