原创力文档dna-platinum thin films for use in chemoradiation therapy studiesdna-platinum薄膜用于放化疗治疗的研究.pdfVIP
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dna-platinum thin films for use in chemoradiation therapy studiesdna-platinum薄膜用于放化疗治疗的研究
Hindawi Publishing Corporation
Bioinorganic Chemistry and Applications
Volume 2012, Article ID 923914, 9 pages
doi:10.1155/2012/923914
Research Article
DNA-Platinum Thin Films for Use in Chemoradiation
Therapy Studies
´
Mohammad Rezaee, Elahe Alizadeh, Darel Hunting, and Leon Sanche
Groupe en Sciences des Radiations, Department de Medecine Nucleaire et Radiobiologie, Faculte de Medecine et des Sciences de la Sante,
´ ´ ´ ´ ´ ´
Universite de Sherbrooke, Sherbrooke, QC, Canada J1H5N4
´
Correspondence should be addressed to Mohammad Rezaee, mohammad.rezaee@usherbrooke.ca
Received 8 July 2011; Accepted 3 August 2011
Academic Editor: Goran N. Kaluderovic
Copyright © 2012 Mohammad Rezaee et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Dry films of platinum chemotherapeutic drugs covalently bound to plasmid DNA (Pt-DNA) represent a useful experimental
model to investigate direct effects of radiation on DNA in close proximity to platinum chemotherapeutic agents, a situation of
considerable relevance to understand the mechanisms underlying concomitant chemoradiation therapy. In the present paper we
determine the optimum conditions for preparation of Pt-DNA films for use in irradiation experiments. Incubation conditions for
DNA platination reactions have a substantial effect on the structure of Pt-DNA in the films. The quantity of Pt bound to DNA as
a function of incubat
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