原创力文档discrete evolutionary genetics multiplicative fitnesses and the mutation-fitness balance离散进化遗传学乘法健身和mutation-fitness平衡.pdfVIP
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discrete evolutionary genetics multiplicative fitnesses and the mutation-fitness balance离散进化遗传学乘法健身和mutation-fitness平衡
Applied Mathematics , 2011, 2, 11-22
doi:10.4236/am.2011.21002 Published Online January 2011 (http://www.SciRP.org/journal/am)
Discrete Evolutionary Genetics: Multiplicative Fitnesses
and the Mutation-Fitness Balance
1 2
Thierry Huillet , Servet Martinez
1
Laboratoire de Physique Théorique et Modélisation, CNRS-UMR 8089, Université de Cergy-Pontoise,
Cergy-Pontoise, France
2Departamento de Ingeniería Matemática, Centro Modelamiento Matemático, UMI 2807,
UCHILE-CNRS, Santiago, Chile
E-mail : Thierry.Huillet@u-cergy.fr, smartine@dim.uchile.cl
Received June 18, 2010; revised October 16, 2010; accepted October 20, 2010
Abstract
We revisit the multi-allelic mutation-fitness balance problem especially when fitnesses are multiplicative.
Using ideas arising from quasi-stationary distributions, we analyze the qualitative differences between the
fitness-first and mutation-first models, under various schemes of the mutation pattern. We give some sto-
chastic domination relations between the equilibrium states resulting from these models.
Keywords: Evolutionary Genetics, Fitness Landscape, Selection, Mutation, Stochastic Models,
Quasi-Stationarity
1. Introduction and Outline (and the References therein) for the relation of a muta-
tion/selection model with ancestral branching processes.
A recent discussion on a Ma
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