dopamine receptor d3r and d4r mrna levels in peripheral lymphocytes in patients with schizophrenia correlate with severity of illness多巴胺受体d3r d4r mrna水平在精神分裂症患者外周淋巴细胞与疾病的严重程度.pdfVIP

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dopamine receptor d3r and d4r mrna levels in peripheral lymphocytes in patients with schizophrenia correlate with severity of illness多巴胺受体d3r d4r mrna水平在精神分裂症患者外周淋巴细胞与疾病的严重程度.pdf

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dopamine receptor d3r and d4r mrna levels in peripheral lymphocytes in patients with schizophrenia correlate with severity of illness多巴胺受体d3r d4r mrna水平在精神分裂症患者外周淋巴细胞与疾病的严重程度

Open Journal of Psychiatry, 2011, 1, 33-39 OJPsych doi: 10.4236/ojpsych.2011.12006 Published Online July 20 11 (http://www.SciRP.org/journal/OJPsych/). Dopamine receptor D3R and D4R mRNA levels in peripheral lymphocytes in patients with schizophrenia correlate with severity of illness 1 1,2,3* 4 5 6 Mitsuhiko Kawano , Ken Sawada , Emi Tsuru , Makoto Nishihara , Kunio Kato , William G. Honer3, Shinji Shimodera1, 7 1Department of Neuropsychiatry, Kochi Medical School, Kochi, Japan; 2Department of Psychiatry, Geiyo Hospital, Kochi, Japan; 3Department of Psychiatry, University of British Columbia, Vancouver, Canada; 4Division of Laboratory Animal Science, Kochi University, Kochi, Japan; 5Multidisciplinary Pain Centre, Aichi Medical University, Aichi, Japan; 6Morinomidori Mental Clinic, Yokohama, Japan; 7Orygen Research Center, University of Melbourne, Australia. * E-mail: sawadak@kochi-u.ac.jp Received 16 May 20 11; revised 20 June 2011; accepted 29 June 2011. ABSTRACT of schizophrenia. Schizophrenia is a disease that affects many areas of Keywords: Dopamine receptor D3R; Dopamine the brain. The dopamine hypothesis is one of the receptor D4R; Schizophrenia; RT-PCR; Lymphocyte; most widely-accepted ideas in the pathophysiology of Cognitive function schizophrenia. Besides alterations in the dopaminer- gic system in the central nervous system, there have 1. INTRODUCTION been several reports of changes in dopaminergic sys