胶原贴敷料治疗面部激素依赖性皮炎临床观察.docVIP

胶原贴敷料治疗面部激素依赖性皮炎临床观察[摘要]目的：观察胶原贴敷料治疗面部激素依赖性皮炎的临床疗效和安全性。方法：将108例面部激素依赖性皮炎患者随机分为两组，治疗组：56例，面部给予胶原贴敷料，每天1次；对照组：52例，面部维生素E霜外涂，每天2次。两组均给予口服西替利嗪10mg，每天1次，疗程均为8周，治疗结束后进行两组疗效对比。结果：疗程结束后两组患者的症状、体征均有不同程度好转，治疗组4周、8周有效率分别为82.14%、91.07%，对照组4周、8周有效率分别为61.84%、65.38%，两组疗效比较差异有统计学意义，且观察组未发生不良反应。结论：胶原贴敷料治疗面部激素依赖性皮炎安全、有效。 [关键词]胶原贴敷料；面部激素依赖性皮炎；治疗 [中图分类号]R758.22[文献标识码]A[文章编号]1008-6455（2011）05-0811-04 Clinical observation ontreatmentfacial hormone-dependent dermatitiswith collagen dressing WANG Ming-zhi （Department of Dermatology,Houjie Hospital of Dongguan City, Dongguan 523945,Guangdong，China） Abstract：Objective To observe the treatment efficiency and safety ofcollagen dressing that it was applied facialhormone-dependent dermatitis. Methods 108 patients suffering from facial hormone-dependent dermatitis were randomly divided into two group.The observation group 56 cases were given collagen dressing once a day.The control group 52 cases were givenVitamin E frost twice a day.Both group were treated with oral cetirizine 10mg once a day,a course of 8 weeks after end of treatment,two groups were compared. Results The two groups of patients after treatment,the symptoms and signs improved in varying degrees,the observation group for 4 weeks, 8 weeks,effective rates were 82.14%，91.07%,control group for 4 weeks,8 weeks were 61.84 %，65.38% efficient,The difference between the two groups was statistically significant, and the observation group had no adverse reactions.Conclusions The collagen dressing treatment of facial hormone-dependent dermatitis is safe and effective. Key words：collagen dressing；facialhormone-dependent dermatitis;treatment 糖皮质激素具有抗过敏、抗炎和免疫抑制等作用，对许多皮肤病有较好疗效，由于其滥用导致的激素依赖性皮炎在临床上比较多见，特别是中青年女性有逐年增加的趋势。因本病好发于颜面部，不仅影响患者面部容貌美，而且还会造成患者面部不适或瘙痒，影响其自信，所以随着人们生活水平的提高，对本病的防治日益受到关注。2007年1月～2009年10月,我们采用胶原贴敷料治疗面部激素依赖性皮炎患者，取得了满意疗效，现将结果报道如下。 1资料和方法 1.1 一般资料:108例面部激素依赖性皮炎患者均来自我院皮肤科门诊，其中男23例，女85例；年龄18～60岁，平均28.6岁。外用含糖皮质激素的软膏最短30天，最长3年，平均10.9个月。将患者单盲随机分为两组：治疗组56例，对照组5