dual treatment strategy by venous ulcers pilot study to dual-frequency ultrasound application双静脉溃疡的治疗策略的初步研究双频超声的应用程序.pdfVIP

Journal of Cosmetics, Dermatological Sciences and Applications, 2011, 1, 157-163 157 doi:10.4236/jcdsa.2011.14024 Published Online December 2011 (http://www.SciRP.org/journal/jcdsa) Dual Treatment Strategy by Venous Ulcers: Pilot Study to Dual-Frequency Ultrasound Application Ilja Kruglikov, Ekaterina Kruglikova WELLCOMET GmbH, Karlsruhe, Deutschland. E-mail: kruglikov@wellcomet.de th st th Received August 24 , 2011; revised October 1 , 2011; accepted October 11 , 2011. ABSTRACT We propose a new dual treatment strategy for venous ulcer, consisting in simultaneous modulation of matrix metallo- proteinases (MMPs) and heat shock proteins (HSPs) in the wound. One treatment method which can efficiently modu- late both these substances is based on the application of dual-frequency ultrasound (LDM). This strategy was checked in a pilot study on 10 patients with chronic venous ulcers an d demonstrated excellent healing rate. Keywords : Venous Ulcer, Dual-Frequency Ultrasound, Matrix Metalloproteinases, Heat Shock Proteins 1. Introduction Recently two new ideas were proposed. One is based on the over-expression of MMPs in the wound bed (see Chronic wounds (CWs) are the wounds which show no e.g. [3-5]), another is connected with the under-expres- healing tendency during the first 12 weeks of the treat- sion of heat shock proteins (HSPs) in the wound under ment or do not heal in 12 months. CWs belong to the some attendant circumstances [6-9]. Several treatment worldwide most severe health problems not only because strategies based on these theories were d