原创力文档effect of biejiajian oral liquid on the expression of raas in hepatic fibrosis ratsbiejiajian口服液对肝纤维化大鼠的老城的表达.pdfVIP
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effect of biejiajian oral liquid on the expression of raas in hepatic fibrosis ratsbiejiajian口服液对肝纤维化大鼠的老城的表达
Pharmacology Pharmacy, 2012, 3, 322-327
/10.4236/pp.2012.33043 Published Online July 2012 (http://www.SciRP.org/journal/pp)
Effect of Biejiajian Oral Liquid on the Expression of RAAS
in Hepatic Fibrosis Rats
*
Li Yao , Yun-Long Zhang, Jue Li, Jing Yu, Yan Peng
Pharmacy College of Zhejiang Chinese Medical University, Hangzhou, China.
*
Email: ylyj@
Received March 14th, 2012; revised April 26th, 2012; accepted May 29th, 2012
ABSTRACT
Objective: To study the effect of Biejiajian Oral Liquid (BOL) on the rennin angiotensin aldosterone system (RAAS) in
plasma of hepatic fibrosis rats and in hepatic stellate cell (HSC) of normal rats. We explore the mechanism of BOL on
inhibiting the activation of HSC and illustrate its mechanism of anti-hepatic fibrosis further. Methods: SD Rats were
divided into 5 groups randomly: normal control group, model group, Enalapril group and BOL groups with different
concentration (2.0 g/ml or 1.0 g/ml). Every group was administered with CCl4 and olive oil solution to induce hepatic
fibrosis except normal one. Each group was treated with the respective drug for 5 weeks and then got the blood. The
level of renin, angiotensin II and aldosterone in the plasma of liver fibrosis rats were detected by the radioimmunoassay.
By using reverse transcription-polymerase chain reaction (RT-PCR) to measure the gene expression of the rennin, ACE,
angiotensinogen, AT1R and ALD. The AT1R gene expression in normal HSC was determined by the immunohisto-
chemical measurement. Results: BOL could effectively reduce the activity of the PRA, AngIIand ALD, which showed
a significant effect on the inhibition of the AngII (P 0.01). Meanwhile, compared with the normal control group, there
was a notable inhibitory action on the PRA of HSC which was administrated by serum containing BOL (P 0.05). And
yet, drug applied group showed no difference with the model group for other factors of the RAAS. Conclusion: BOL
can inhibit th
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