effect of benzothiazoline ligand and corresponding organoantimony(v) derivative on the reproductive system of male ratsbenzothiazoline配体的影响和相应organoantimony(v)导数对雄性小鼠的生殖系统.pdfVIP

Hindawi Publishing Corporation Bioinorganic Chemistry and Applications Volume 2006, Article ID 20979, Pages 1–7 DOI 10.1155/BCA/2006/20979 Effect of Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative on the Reproductive System of Male Rats D. Shanker,1 A. K. Rai,1 Y. P. Singh,1 H. Rehwani,2 V. Khushalani,2 and R. S. Gupta2 1 Department of Chemistry, University of Rajasthan, Jaipur 302004, India 2 Reproduction Physiology Section, Department of Zoology, University of Rajasthan, Jaipur 302004, India Received 24 September 2004; Revised 5 February 2005; Accepted 1 March 2005 Benzothiazoline HNC H SC(C H )CH : C(OH)COOCH 1 prepared by the condensation reaction of aroyl pyruvate and 2- 6 4 6 5 3 i aminothiophenol has been treated with Ph Sb(OPr ) to yield Ph Sb[SC H NC(C H )CH : COCOOCH ] 2. These compounds 3 2 3 6 4 6 5 3 have been characterized by elemental analyses and molecular weight determinations. The probable structures of the ligand as well as antimony complex have been tentatively proposed on the basis of IR and NMR (1H and 13C) spectral evidences. Both com- pounds have been tested for their antifertility activity in male albino rats. The oral administration of compounds 1 and 2 at the dose level of 10 mg/rat/day significantly reduced the weights of testes, epididymides, ventral prostate, and seminal vesicles. The production of preleptotene spermatocytes was decreased by 36.57%; 57.23%, pachytene spermatocytes by 40.06%; 62.01%, and secondary spermatocytes by 52.45%; 63.22%, following the treatment of