effect of phlorizin on metabolic abnormalities in spontaneously diabetic torii (sdt) rats根皮甙对代谢异常的影响在自发糖尿病鸟居(sdt)老鼠.pdfVIP

Vol.2, No.2, 113-118 (2012) Open Journal of Animal Sciences /10.4236/ojas.2012.22016 Effect of phlorizin on metabolic abnormalities in Spontaneously Diabetic Torii (SDT) rats 1,2 2 1,2 1,2* Takeshi Ohta , Hisayo Morinaga , Takuji Yamamoto , Takahisa Yamada 1Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Kyoto, Japan 2Laboratory of Animal Genetics, Graduate School of Science and Technology, Niigata University, Niigata, Japan; * Corresponding Author: tyamada@agr.niigata-u.ac.jp Received 12 December 2011; revised 12 January 2012; accepted 6 February 2012 ABSTRACT the onset of diabetes. The glucose intolerance was inves- tigated at 12 and 16 weeks of age [10-12]. SDT rats show The Spontaneously Diabetic Torii (SDT) rat is a a remarkable hyperglycemia after the onset of diabetes novel model for nonobese type 2 diabetes. In mellitus. this study we investigated the glycolipid meta- Phlorizin is an antidiabetic agent that is found primar- bolic changes with phlorizin-treatment, which in- ily in apple peels [13]. Phlorizin inhibits intestinal glu- hibits intestinal glucose uptake and renal glu- cose uptake via the sodium D-glucose cotr