effect of pulmonary rehabilitation on oxidative stress in patients with pulmonary diseases肺康复对氧化应激的影响患者的肺部疾病.pdfVIP

Advances in Bioscience and Biotechnology, 2012, 3, 1028-1036 ABB /10.4236/abb.2012.327125 Published Online November 2012 (http://www.SciRP.org/journal/abb/) Effect of pulmonary rehabilitation on oxidative stress in patients with pulmonary diseases Masayuki Itoh, Kenji Nemoto, Takao Tsuji, Hiroyuki Nakamura, Kazutetsu Aoshiba Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan Email: kaoshiba@tokyo-med.ac.jp Received 12 August 2012; revised 14 September 2012; accepted 6 October 2012 ABSTRACT severe oxidative stress even when the exercise load is mild [3]. Exercise-training-based pulmonary rehabilitation has been confirmed to be effective in improving the acti- 2. OXIDATIVE STRESS IN THE vities of daily living (ADL) and relieving the dysp- MUSCLES OF COPD PATIENTS nea of chronic obstructive pulmonary disease (COPD) patients. Exercise training increases the antioxidant As a result of the effects of decreased daily activities and capacity of COPD patients, but since strenuous exer- of generalized inflammation and oxidative stress, the cise and acute exercise loading have the opposite ef- cross-sectional area of the quadriceps femoris muscle of fect and increase oxidative stress, it is important to COPD patients decreases, and there is a decrease in the establish exercise training conditions that efficiently number of type I fibers (slow-twitch fibers), which have raise antioxidant capacity without increasing oxida- endurance strength, and an increase in the proportion tive st