efficacy and tolerability of propolis special extract gh 2002 as a lip balm against herpes labialis a randomized, double-blind three-arm dose finding study疗效和耐受性的蜂胶特殊提取gh 2002作为随机对口唇疱疹的唇膏,双盲三臂剂量发现研究.pdfVIP

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efficacy and tolerability of propolis special extract gh 2002 as a lip balm against herpes labialis a randomized, double-blind three-arm dose finding study疗效和耐受性的蜂胶特殊提取gh 2002作为随机对口唇疱疹的唇膏,双盲三臂剂量发现研究.pdf

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efficacy and tolerability of propolis special extract gh 2002 as a lip balm against herpes labialis a randomized, double-blind three-arm dose finding study疗效和耐受性的蜂胶特殊提取gh 2002作为随机对口唇疱疹的唇膏,双盲三臂剂量发现研究

Vol.3, No.1, 49-55 (2011) Health doi:10.4236/health.2011.31010 Efficacy and tolerability of propolis special extract GH 2002 as a lip balm against herpes labialis: a randomized, double-blind three-arm dose finding study Simona Holcová1*, Marie Hladiková2 1Outpatient Department of Dermatovenerology, Brno, Czech Republic; *Corresponding Author: simona.holcova@email.cz 2Department for Medical Informatics, 2nd Medical Faculty of the Charles University, Prague, Czech Republic; statistika.hladikova@seznam.cz Received 11 October 2010; revised 17 November 2010; accepted 19 November 2010. ABSTRACT various consecutive stages. An episode begins with a prodromal phase with local pain, tingling and burning, A dose-finding study was performed with re- followed by erythematous and papular phases with in- spect to the clinical applicability and tolerability flamed and reddened papules, and vesicular phase with of three different concentrations of propolis fluid-filled blisters. Via the ulceration phase or the special extract GH 2002 in a lip balm (0.1%, 0.5% bursting of the vesicle with wound formation it finally and 1%). The trial was designed as a dou- leads to the incrustation and healing phase [1]. ble-b