efficacy of 1-(n-acetyl-6-aminohexyl)-3-hydroxypyridin-4-one (cm1) in treatment of iron-loaded hepatocyte cultures的功效1 -(n-acetyl-6-aminohexyl)3-hydroxypyridin-4-one(cm1)治疗iron-loaded肝细胞的文化.pdfVIP

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efficacy of 1-(n-acetyl-6-aminohexyl)-3-hydroxypyridin-4-one (cm1) in treatment of iron-loaded hepatocyte cultures的功效1 -(n-acetyl-6-aminohexyl)3-hydroxypyridin-4-one(cm1)治疗iron-loaded肝细胞的文化.pdf

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efficacy of 1-(n-acetyl-6-aminohexyl)-3-hydroxypyridin-4-one (cm1) in treatment of iron-loaded hepatocyte cultures的功效1 -(n-acetyl-6-aminohexyl)3-hydroxypyridin-4-one(cm1)治疗iron-loaded肝细胞的文化

Advances in Bioscience and Biotechnology, 2012, 3, 1060-1067 ABB /10.4236/abb.2012.327129 Published Online November 2012 (http://www.SciRP.org/journal/abb/) Efficacy of 1-(N-acetyl-6-aminohexyl)-3-hydroxypyridin- 4-one (CM1) in treatment of iron-loaded hepatocyte cultures 1,2 1 3 4 Kanjana Pangjit , Ratana Banjerdpongchai , Chada Phisalaphong , Suthat Fucharoen , Somdet Srichairatanakool1* 1Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand 2College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, Thailand 3Institute of Research and Development, Government Pharmaceutical Organization, Ministry of Public Health, Bangkok, Thailand 4Thalassemia Research Center, Institute of Molecular Bioscience, Mahidol University Salaya Campus, Nakornpathom, Thailand Email: u4305084@, ratana@chiangmai.ac.th, chada@health.moph.go.th, grsfc@mahidol.ac.th, * ssrichai@med.cmu.ac.th Received 23 August 2012; revised 27 September 2012; accepted 23 October 2012 ABSTRACT electron transfer and catalysis [1]. Secondary iron over- load in β-thalassemia patients is commonly caused by in- Excessive iron is toxic to cells and organelles, where it creased dietary iron absorption and multiple blood trans- can generate harmful reactive oxygen species (ROS) fusions [2]. The iron catalyzes production of reactive resulting in oxidative tissue damage. Liver is the ma-