原创力文档efficacy of artesunate + sulphadoxine-pyrimethamine (as？+？sp) and amodiaquine + sulphadoxine-pyrimethamine (aq？+？sp) for uncomplicated falciparum malaria in equatorial guinea (central africa)英文论文.pdfVIP
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efficacyofartesunatesulphadoxine-pyrimethamine(as？？sp)andamodiaquinesulphadoxine-pyrimethamine(aq？？sp)foruncomplicatedfalciparummalariainequatorialguinea(centralafrica)英文论文
Hindawi Publishing Corporation
Journal of Tropical Medicine
Volume 2009, Article ID 781865, 7 pages
doi:10.1155/2009/781865
Clinical Study
Efficacy of Artesunate + Sulphadoxine-Pyrimethamine (AS + SP)
and Amodiaquine + Sulphadoxine-Pyrimethamine (AQ + SP) for
Uncomplicated falciparum Malaria in Equatorial Guinea
(Central Africa)
Pilar Charle,1 Pedro Berzosa,2 Miguel Angel Descalzo,2 Aida de Lucio,2 Jose Raso,3
Jacqueline Obono,3 Magdalena Lwanga,3 Natividad Nlang,3 Araceli Nchama,3
4 4 4 5 ´ 2
Catalina Mangue, Anastasio Micha, Natividad Nsee, Rosario Mesie, Agustın Benito,
´ 2
and Jesus Roche
1 Centre for the Control of Diseases, Reference Laboratory of Malaria, National Centre of Tropical Medicine—ISCIII,
Malabo, Equatorial Guinea
2 National Centre of Tropical Medicine, Institute of Health Carlos III, 28029 Madrid, Spain
3 Reference Laboratory of Malaria, MINSABS and ISCIII, Malabo, Equatorial Guinea
4 Reference Laboratory of Malaria, MINSABS and ISCIII, Bata, Equatorial Guinea
5 Paediatric Department, Regional Hospital of Malabo, Malabo, Equatorial Guinea
Correspondence should be addressed to Pilar Charle, piluca ch@yahoo.es
Received 6 October 2008; Revised 11 February 2009; Accepted 26 March 2009
Recommended by Sukla Biswas
Objectives. The objectives of the study were (i) to evaluate the efficacy of combination drugs, such as artesunate + sulphadoxine-
pyrimethamine (AS + SP) and amodiaquine + sulphadoxine-pyripethamine (AQ + SP) in treatment of uncomplicated falciparum
malaria (ii) to differentiate recrudescence from reinfection by analysing msp-1 and msp-2 ge
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