原创力文档efficacy of low-dose thiopurine therapy for the induction of remission in steroid-dependent ulcerative colitis comparison with cytapheresis功效的低剂量thiopurine的诱导缓解治疗激素依赖性溃疡性结肠炎与cytapheresis进行比较.pdfVIP
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efficacy of low-dose thiopurine therapy for the induction of remission in steroid-dependent ulcerative colitis comparison with cytapheresis功效的低剂量thiopurine的诱导缓解治疗激素依赖性溃疡性结肠炎与cytapheresis进行比较
Open Journal of Gastroenterology, 2012, 2, 9-14 OJGas
/10.4236/ojgas.2012.21002 Published Online February 2012 (http://www.SciRP.org/journal/ojgas/)
Efficacy of low-dose thiopurine therapy for the induction
of remission in steroid-dependent ulcerative colitis:
Comparison with cytapheresis
*
Shuji Kochi , Shotaro Nakamura, Takayuki Matsumoto
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
*
Email: decorin@intmed2.med.kyushu-u.ac.jp
Received 14 November 2011; revised 23 December 2011; accepted 14 January 2012
ABSTRACT ulcerative colitis (UC), immunomodulatory agents, such
as azathioprine (AZA), 6-mercaptopurine (6-MP), cyclo-
Background: The role of azathioprine (AZA) and 6-
sporine, or methotrexate, have been used for the induc-
mercaptopurine (6-MP) in the induction of remission in
tion and maintenance of clinical remission of the disease
patients with ulcerative colitis (UC) remains unclear.
[1-10]. While thiopurines (AZA/6-MP) are the most
Aims: To compare the efficacy and safety of low-dose
commonly used agents to maintain clinical remission in
thiopurine (AZA/6-MP) and cytapheresis (CAP) for
patients with UC [1,2], the use of AZA/6-MP for in-
the in
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