原创力文档efficacy and tolerance study of an oligopeptide with potential anti-aging activity疗效和耐受性的研究与潜在的抗衰老活性寡肽.pdfVIP
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efficacy and tolerance study of an oligopeptide with potential anti-aging activity疗效和耐受性的研究与潜在的抗衰老活性寡肽
Journal of Cosmetics, Dermatological Sciences and Applications, 2011, 1, 133-140 133
doi:10.4236/jcdsa.2011.14020 Published Online December 2011 (http://www.SciRP.org/journal/jcdsa)
Efficacy and Tolerance Study of an Oligopeptide
with Potential Anti-Aging Activity
1 1 1 2
Athanasia Varvaresou , Spyridon Papageorgiou , Evangelia Protopapa , Alexandra Katsarou
1Department of Aesthetics and Cosmetology, School of Health Caring Professions, Technological Educational Institution, Athens,
Greece; 2Department of Dermatology and Venereology, University of Athens, Athens, Greece, “Andreas Syggros” Venereal Skin
Diseases Hospital of Athens, Athens, Greece.
E-mail: avarvares@teiath.gr, varvaresou@pharm.uoa.gr
th st th
Received September 14 , 2011; revised November 1 , 2011; accepted November 14 , 2011.
ABSTRACT
Background : Oligopeptide-20 acts as positive regulator of cell proliferation and increases collagen and hyaluronic
acid levels in keratinocyte and fibroblast cultures. Methods : After randomization half the face of twenty volunteers was
treated twice daily for two months with the oligopeptide-20 cream (0.003% w/w, 300 ppm) and the other half with the
vehicle. Skin bioengineering was used to estimate the effects on human skin. Results : The average number and width of
wrinkles (Sew, 11.7%, p 0.05) and cyclic average roughness (cR3, 12.2%, p 0.005) were improved. Sesc parameter,
indicative of stratum corneum dehydration was affected almost equally by the oligopeptide and the vehicle cream (p
0.1). Volunteers noted statistically significant improvement regarding fine wrinkles and skin brightness on the peptide
treated side, whereas the skin smoo
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