efficacy of a synbiotic chewable tablet in the prevention of antibiotic-associated diarrhea预防的功效的synbiotic咀嚼片antibiotic-associated腹泻.pdfVIP

Vol.3, No.2, 110-115 (2011) Health doi:10.4236/health.2011.32020 Efficacy of a synbiotic chewable tablet in the prevention of antibiotic-associated diarrhea Charles Spielholz Nutraceutical Medical Research, 445 Hamilton Avenue, Suite 1102, White Plains, New York, 10601. USA. cspielholz@ Received 4 January 2011; revised 24 January 2011; accepted 27 January 2011 ABSTRACT Clostridium Difficile Infection by Clostridium difficile, a complication of treatment with antibiotics, causes antibiotic- 1. INTRODUCTION associated diarrhea (AAD) and can lead to coli- Antibiotics have significantly decreased mortality re- tis and pseudomembranous colitis. Incidence of sulting from infectious disease and increased the success C. difficile infection is increasing among the rates of many medical procedures such as surgery. elderly undergoing antibiotics therapy confined However, use of antibiotics also causes significant losses to health care facilities, conditions that are ex- to the population of beneficial microbiota residing in the pensive to treat, decrease the quality of life and digestive tract. The digestive tract is the front line of are life threatening. Use of probiotics has been defense against infection, representing a significant por- proposed as a method to decrease the inci- tion of the total immune system [1]. Loss of native pop- dence of AAD in health care facilities. To exam- ulations of beneficial microbiota exposes the intestinal ine the efficacy of using probiotics, 120 nursing mucosa and allows non-beneficial