醋酸曲安奈德联合醋酸泼尼松治疗婴幼儿脉管性疾病.docVIP

醋酸曲安奈德联合醋酸泼尼松治疗婴幼儿脉管性疾病[摘要]目的:探讨局部注射醋酸曲安奈德联合口服醋酸泼尼松控制性治疗婴幼儿脉管性疾病的疗效。方法:本组患儿23例,瘤体面积0.6cm×1cm～5cm×6cm,初次治疗年龄为2个月～1岁。口服醋酸泼尼松第1～10周,3.0～5.0mg/kg,总量不超过50kg,隔日早晨顿服。根据瘤体大小注射曲安奈德,面积较大或多发者可采取分次注射治疗,2周注射1次,如瘤体持续消退,则无需再次注射,如瘤体有再次扩大的趋势,需重复注射,注射后2周随访1次。结果:23例患儿,显效17例(74.0%),有效5例(21.7%),无效1例(4.3%),有效率达95.7%。结论:局部注射醋酸曲安奈德联合口服醋酸泼尼松控制性治疗婴幼儿脉管性疾病,操作简单、经济、无需手术,可获得较好的疗效。 [关键词]婴幼儿脉管性疾病; 糖皮质激素; 口服;注射治疗 [中图分类号]R732.2 [文献标识码]A [文章编号]1008-6455(2010)08-1188-03 To treat infant vascular anomalies with Triamcinolone Acetonide and Prednisone Acetate LU Yan,BAI Yu-qin,JIN Min,XIANG Yan,ZHANG Xin-xia,GUO Ai-di,Li Tong (Orthopaedicswomem-infant Health Care Hospital of Lanzhou,Lanzhou 730000,Gansu,China) Abstract:Objective To discuss the curative effect of injecting Triamcinolone Acetonide locally treating infant hemangioma controlly with taking Prednisoneacetate orally.Methods 23 infants in the team, tumour proportion: 0.6cm×1cm～5cm×6cm, the age of infant be treated firstly: 2 months to 1 year old, the first week to the tenth week of taking Prednisone acetate orally, 3.0～5.0mg/kg, the gross less than 50kg, taken at a draught in tertian morning. Follow up one time after 2 weeks of the injection.ResultsExcellence: 17cases(74.0%),utility: 5cases(21.7%),ineffective: 1cases(4.3%).ConclusionIn this team, 23 cases got better effect by injecting Triamcinolone Acetonide locally treating infant hemangioma on body surface controlly with taking Prednisone Acetate orally.The operation is simple and inexpensive ,without surgery. Key words:infant vascular anomalies; glucocorticoid; oral;inject treating 脉管性疾病包括血管瘤和脉管畸形二大类[1],多见于婴儿出生时或出生后不久,可发生于全身体表各个部位,发生于眼睑、外鼻、耳廓、口唇等部位的病变,除了给患者造成美容缺陷外,还可引起相应功能障碍,给患者及其亲属带来极大的精神创伤和心理负担,故患者求治心切。2007年9月～2009年5月,我们采用局部注射醋酸曲安奈德联合口服醋酸泼尼松治疗婴幼儿脉管性疾病23例,效果满意,现报道如下。 1临床资料 本组患儿23例,年龄2个月～1岁,皮损部位:唇部4例,面颊部7例,鼻部2例,眼睑部6例,四肢4例。瘤体面积:0.6cm×1cm～5cm×6cm,其中血管瘤(旧称草莓状血管瘤)18例,静脉畸形(旧称海绵状血管瘤)5例。 2治疗方法 治疗前给予咪达唑仑、芬太尼、丙泊酚复合静脉麻醉以减轻患儿的疼痛。注射方法: 根据瘤体大小,抽取含量50mg/5ml一支的醋酸曲安奈德1～2m