鼻咽癌调强放疗优化程序疗效.docVIP

鼻咽癌调强放疗优化程序疗效[摘要]目的探讨鼻咽癌调强放疗优化程序的疗效。方法奈达铂+紫杉醇方案化疗二周期,全程实施IMRT对鼻咽、全颈及锁骨上的治疗。结果①有效性,在调强放疗优化程序治疗全部结束后,原发灶和颈淋巴结完全消退率CR93.5%(29/41)和90.3%(28/41);疗程结束三个月后,原发灶和颈淋巴结完全消退率CR100%(41/41)和96.8%(30/41)。②不良毒副反应,治疗结束后经每3个月复查后未发现有肿瘤复发及严重晚期放射损伤,治疗期间由调强放疗和化疗引起不良毒副作用经适宜方法处理后易得到较理想控制。 [关键词]鼻咽肿瘤;紫杉醇+奈达铂;调强放疗;毒副反应 [中图分类号]R739.6[文献标识码]B [文章编号] 1005-0515(2010)-7-004-03 The Short-term Clinical Observation of Nedaplatin and Paclitaxel Chemotherapy Combination Intensity Modulated Radiationtherapy(IMRT) In First-treated Nasopharyngeal Carcinoma LI GUI MEI1HE XIA2TAN YAN1 (TheoncologydepartmentofJiangsuYangzhouHongquanHospital,JiangDu225200) [Abstract]ObjectiveThe Short-term Clinical efficacy and the side reaction of Nedaplatin and Paclitaxel Chemotherapy Combination Intensity Modulated Radiationtherapy(IMRT) in First-treated Nasopharyngeal Carcinoma. Methods All patients with Nasopharyngeal Carcinoma have been treated by two cycle`s induction chemotherapy with Nedaplatin and Paclitaxel;IMRT including nasopharynx and full neck to supraclavicle. Results After the treatment,the complete response rates of the primary lesions and cervical nodes were CR93.5%(29/41) and 90.3%(28/41),which were CR100%(41/41)和96.8%(30/41)3months after treatment. Main adverse effects were myelosuppression,the acute skin toxicity and mucosit. ConclusionThe short term response of Nedaplatin and Paclitaxel chemotherapy plus and before radiotherapy for nasopharyngeal carcinoma patients is preferable and the toxicity is tolerable. [Keywords]Nasopharyngeal neoplasms;Intensity modulated radiation therapy;Chemotherapy;Nedaplatin 目前鼻咽癌的同期放化疗依然存在一些问题,如哪种化疗药物或药物组合为最佳,药物的剂量强度是多少,放疗与化疗如何配合,是在外照射期间应用化疗,还是在后装治疗时应用化疗,巩固化疗的价值如何等,而利用药物结合调强放疗优化程序的疗效却能在一定程度上解决以上问题。我们应用紫杉醇+奈达铂诱导结合调强放疗程序治疗鼻咽癌,通过分析调强放疗程序治疗有效性及不良反应,发现该方案治疗鼻咽癌有效率比较高,副作用有明显降低趋势。因此笔者分析研究江苏省肿瘤医院收治的41例鼻咽癌患者的资料,对调强放疗优化程序治疗鼻咽癌的疗效作以研究报导。 1 资料与方法 1.1 临床资料 自2007年02月17日至2008年06月24日期间,江苏省肿瘤医院收治经鼻咽活检诊断为鼻咽癌患者有41例,其中男性29例,女性12例,年龄范围17-70岁,平均为45.5岁, KPS≥80分。经病