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南极海冰冰穴和冰川冰及其对水团-极地研究
/scientificreports
OPEN Novel avian influenza A (H5N6)
viruses isolated in migratory
waterfowl before the first human
received: 21 March 2016 case reported in China, 2014
Accepted: 23 June 2016
Published: 19 July 2016 1,3,4,* 2,* 2,* 1 5 2
Yuhai Bi , Haizhou Liu , Chaochao Xiong , Di Liu , Weifeng Shi , Mingxin Li ,
2 6 6 6 6 6
Siling Liu , Jing Chen , Guang Chen , Yong Li , Guoxiang Yang , Yongsong Lei ,
6 7 2 2,4 2,4
Yanping Xiong , Fumin Lei , Hanzhong Wang , Quanjiao Chen , Jianjun Chen
George F. Gao1,3,4,8,9
In May 2014, China formally confirmed the first human infection with the novel H5N6 avian influenza
virus (AIV) in Sichuan Province. Before the first human case was reported, surveillance of AIVs in wild
birds resulted in the detection of three H5N6 viruses in faecal samples from migratory waterfowl in
Chenhu wetlands, Hubei Province, China. Genetic and phylogenetic analyses revealed that these
three novel viruses were closely related to the H5N6 virus that has caused human infections in
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