a concise review of amyloidosis in animals淀粉样变的简洁回顾动物.pdfVIP

Hindawi Publishing Corporation Veterinary Medicine International Volume 2012, Article ID 427296, 11 pages doi:10.1155/2012/427296 Review Article A Concise Review of Amyloidosis in Animals Moges Woldemeskel Tifton Veterinary Diagnostic and Investigational Laboratory, Department of Pathology, College of Veterinary Medicine, The University of Georgia, 43 Brighton Road, Tifton, GA 31793, USA Correspondence should be addressed to Moges Woldemeskel, mwoldem@ Received 11 October 2011; Revised 15 December 2011; Accepted 5 January 2012 Academic Editor: Pedro J. Ginel Copyright © 2012 Moges Woldemeskel. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Amyloidosis refers to a group of protein misfolding diseases characterized by deposition of a particular amyloid protein in various organs and tissues of animals and humans. Various types and clinical forms of amyloidosis, in which the pathology and pathogenesis is diverse depending upon the underlying causes and species affected, are reported in domestic and wild animals. The clinical findings are also quite variable consequent to the variation of the tissues and organs involved and the extent of functional disruption of the affected organs in various animal species. The affected organs may be enlarged and exhibit variable pallor grossly, or the amyloid deposit may be discernible only after microscopic examination of the affected tissues. Amyloid appears as a pale eosinophilic homogenous extracellular deposit in tissues. However, microscopic examination and Congo red staining with green birefringence under polarized light are needed to