acute renal replacement therapy in pediatrics在儿科急性肾脏替代治疗.pdfVIP

SAGE-Hindawi Access to Research International Journal of Nephrology Volume 2011, Article ID 785392, 8 pages doi:10.4061/2011/785392 Research Article Acute Renal Replacement Therapy in Pediatrics Rajit K. Basu,1, 2 Derek S. Wheeler,1, 2 Stuart Goldstein,2, 3 and Lesley Doughty1, 2 1 Division of Critical Care and Center for Acute Care Nephrology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA 2 Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA 3 Division of Nephrology and Center for Acute Care Nephrology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA Correspondence should be addressed to Rajit K. Basu, rajit.basu@ Received 14 February 2011; Accepted 4 April 2011 Academic Editor: Michel Fischbach Copyright © 2011 Rajit K. Basu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Acute kidney injury (AKI) independently increases morbidity and mortality in children admitted to the hospital. Renal replace- ment therapy (RRT) is an essential therapy in the setting of AKI and fluid overload. The decision to initiate RRT is complex and often complicated by concerns related to patient hemodynamic and thermodynamic instability. The choice of which RRT modality to use depends on numerous criteria that are both patient and treatment center specific. Surprisingly, despite decades of use, no randomized, controlled trial study involving RRT in pediatrics has been performed. Because of these factors, clear-cut consensus is lacking regarding key questions surrounding RRT delivery. In this paper, we will summari