acute renal replacement therapy in children with diarrhea-associated hemolytic uremic syndrome a single center 16 years of experience急性肾脏替代疗法在儿童diarrhea-associated溶血性尿毒症综合征单一中心16年的经验.pdfVIP

SAGE-Hindawi Access to Research International Journal of Nephrology Volume 2011, Article ID 930539, 4 pages doi:10.4061/2011/930539 Clinical Study Acute Renal Replacement Therapy in Children with Diarrhea-Associated Hemolytic Uremic Syndrome: A Single Center 16 Years of Experience Silviu Grisaru, Melissa A. Morgunov, Susan M. Samuel, Julian P. Midgley, Andrew W. Wade, James B. Tee, and Lorraine A. Hamiwka Division of Pediatric Nephrology, Department of Pediatrics, Alberta Children’s Hospital, University of Calgary, 2888 Shaganappi Trail NW, Calgary, AB, Canada T3B 6A8 Correspondence should be addressed to Silviu Grisaru, sgrisaru@ucalgary.ca Received 31 August 2010; Revised 18 January 2011; Accepted 23 March 2011 Academic Editor: A. Davenport Copyright © 2011 Silviu Grisaru et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Acute kidney injury (AKI) is becoming more prevalent among hospitalized children, its etiologies are shifting, and new treatment modalities are evolving; however, diarrhea-associated hemolytic uremic syndrome (D+HUS) remains the most common primary disease causing AKI in young children. Little has been published about acute renal replacement therapy (ARRT) and its challenges in this population. We describe our single center’s experience managing 134 pediatric patients with D+HUS out of whom 58 (43%) required ARRT over the past 16 years. In our cohort, all but one patient were started on peritoneal dialysis (PD). Most patients, 47 (81%), received acute PD on a pediatric inpatient ward. The most common recorded complications in our cohort were peritoneal fluid leaks 13 (22%), peritonit