advances in endoscopic visualization of barrett’s esophagus the role of confocal laser endomicroscopy先进的内窥镜可视化巴雷特食管的共焦激光endomicroscopy的角色.pdfVIP

Hindawi Publishing Corporation Gastroenterology Research and Practice Volume 2012, Article ID 493961, 5 pages doi:10.1155/2012/493961 Review Article Advances in Endoscopic Visualization of Barrett’s Esophagus: The Role of Confocal Laser Endomicroscopy ` Helga Bertani, Flavia Pigo, Emanuele Dabizzi, Marzio Frazzoni, Vincenzo Giorgio Mirante, Mauro Manno, Raffaele Manta, and Rita Conigliaro Endoscopy Unit, Nuovo Ospedale Civile S. Agostino Estense, Via Giardini 1355, Baggiovara, 41126 Modena, Italy Correspondence should be addressed to Helga Bertani, helga88@libero.it Received 31 October 2011; Revised 19 December 2011; Accepted 22 December 2011 Academic Editor: Giovanni Domenico de Palma Copyright © 2012 Helga Bertani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Many endoscopic imaging modalities have been developed and introduced into clinical practice to enhance the diagnostic capabilities of upper endoscopy. In the past, detection of dysplasia and carcinoma of esophagus had been dependent on biopsies taken during standard white-light endoscopy (WLE). Recently high-resolution (HR) endoscopy enables us to visualize esophageal mucosa but resolution for glandular structures and cells is still low. Probe-based confocal laser endomicroscopy (pCLE) is a new promising diagnostic technique by which details of glandular and vascular structures of mucosal layer can be observed. However, the clinical utility of this new diagnostic tool has not yet been fully explored in a clinical setting. In this paper we will highlight this new technique for detection of