bdkrb2 +9？9 polymorphism is associated with higher risk for diabetes mellitus in the brazilian general populationbdkrb2 + 9 9多态性与糖尿病在巴西的风险高于一般人群.pdfVIP

Hindawi Publishing Corporation Experimental Diabetes Research Volume 2012, Article ID 480251, 4 pages doi:10.1155/2012/480251 Research Article BDKRB2 +9/−9 Polymorphism Is Associated with Higher Risk for Diabetes Mellitus in the Brazilian General Population Rafael de Oliveira Alvim,1 Paulo C. J. L. Santos,1 Raimundo M. Nascimento,2 2 ´ 3 ´ 1 1 George L. L. M. Coelho, Jose G. Mill, Jose E. Krieger, and Alexandre C. Pereira 1 Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Avenida Dr. Eneas de Carvalho Aguiar, 44 Cerqueira Cesar, 05403-000 Sao Paulo, SP, Brazil ´ ´ ˜ 2 Department of Medicine, Ouro Preto Federal University, Ouro Preto, MG, Brazil 3 Department of Physiology, Espirito Santo Federal University, Vitoria, ES, Brazil ´ Correspondence should be addressed to Alexandre C. Pereira, acplbmpereira@ Received 3 October 2012; Accepted 1 November 2012 Academic Editor: Aristidis Veves Copyright © 2012 Rafael de Oliveira Alvim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Some mechanisms have been proposed to explain the role of bradykinin on glucose homeostasis and some studies reported that the BDKRB2 +9/−9 polymorphism was associated to the transcriptional activity of the receptor. In this scenario, the main aim of thi