cardiovascular risk in patients with psoriatic arthritis银屑病关节炎患者患心血管疾病的风险.pdfVIP

Hindawi Publishing Corporation International Journal of Rheumatology Volume 2012, Article ID 714321, 11 pages doi:10.1155/2012/714321 Review Article Cardiovascular Risk in Patients with Psoriatic Arthritis Tracy Y. Zhu, Edmund K. Li, and Lai-Shan Tam Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong Correspondence should be addressed to Lai-Shan Tam, lstam@.hk Received 10 January 2012; Revised 14 February 2012; Accepted 21 February 2012 Academic Editor: George D. Kitas Copyright © 2012 Tracy Y. Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. In addition to skin and joint involvement, there is increasing evidence suggesting that patients with PsA also have an increase in risk of clinical and subclinical cardiovascular diseases, mostly due to accelerating atherosclerosis. Both conventional and nonconventional cardiovascular risk factors contribute to the increased cardiovascular risk in PsA. Chronic inflammation plays a pivotal role in the pathogenesis of atherosclerosis in PsA, acting independently and/or synergistically with the conventional risk factors. In this paper, we discuss the current literature indicating that patients with PsA are at risk of cardiovascular diseases. 1. Introduction atherosclerosis”, “endothelial function”, “lipids”, “hyperten- sion”, “diabetes mellitus”, “homocysteine”, or “acute-phase Psoriatic arthri